DOSING
1 Injection, Every 4 Weeks After 2 or 3 Starter Injections Depending
on Weight
Children with ulcerative colitis will receive SIMPONI® as an injection under the skin (subcutaneous injection)
with the prefilled syringe. Use SIMPONI® exactly as prescribed by your doctor. Your doctor will tell you how
much SIMPONI® to inject and when to inject it.
The recommended SIMPONI® subcutaneous dosage for children weighing at least 33 pounds (15 kg) with
moderately to severely active UC is based on body weight as shown in the table below:
| Pediatric Weight | Week 0 | Week 2 | Week 6 and every 4 weeks thereafter |
|---|---|---|---|
| 40 kg and greater | 200 mg | 100 mg | 100 mg |
| At least 15 kg to less than 40 kg | 100 mg | 50 mg | 50 mg |
- For pediatric patients weighing 15 kg or greater, administer the appropriate dose using the prefilled syringe (50 mg/0.5 mL or 100 mg/mL)
SIMPONI® requires just 12 maintenance injections under the skin every 4 weeks after 2 or 3 starter injections
during the first year of treatment. Humira® (adalimumab), another TNF blocker, requires twice as many
maintenance injections during the first year of treatment.
SIMPONI® (golimumab)*
INDUCTION
Week 0
1 or 2 injections depending on patient's body weight
Week 2
MAINTENANCE
1 injection at Week 6 and every 4 weeks
thereafter
14 OR 15
TOTAL INJECTIONS PER FIRST YEAR
Humira®*†
INDUCTION
Day 1
1 or 2 injections depending on patient's body weight
Day 8
Day 15
MAINTENANCE
Starting on Day 29, 1 injection every 2 weeks
28 OR 29
TOTAL INJECTIONS PER FIRST YEAR‡
OR
INDUCTION
Day 1
1 or 2 injections depending on patient's body weight
Day 8
Day 15
MAINTENANCE
Starting on Day 29, 1 injection every week
52 OR 53
TOTAL INJECTIONS PER FIRST YEAR‡
This chart is not intended to compare the safety, effectiveness, or uses of these treatments. While dosing may be important, there are other factors to consider. Talk to your child's healthcare provider about treatment options and what might be right for them.
*Trademarks are the property of their respective owners.
†Humira® is indicated for the treatment of moderately to severely active ulcerative colitis in pediatric patients 5 years of age and older.
‡Number of Humira® induction injections calculated using 80-mg, 40-mg, and 20-mg formulations.
If your doctor decides that you, your child, or a caregiver may be able to give your injections of SIMPONI® at home, you should receive training on the right way to prepare and inject SIMPONI®. Do not try to inject SIMPONI® yourself until you have been shown the right way to give the injections by your doctor or nurse.
- Adults and children 12 years of age and older may self-inject with SIMPONI® prefilled syringe
- Only adults may self-inject with SIMPONI® SmartJect® autoinjector
Please refer to the Medication Guide and Instructions for Use, included with your SIMPONI® medicine, for more information on injecting with SIMPONI®.
SIMPONI® is intended for use under the guidance and supervision of a doctor.
At-Home Injections With the SIMPONI® Prefilled Syringe
For Pediatric Patients Depending on the Child's Weight
If your doctor decides that you, your child, or a caregiver may be able to give your injections of SIMPONI® at home, you should receive training on the right way to prepare and inject SIMPONI®. Do not try to inject SIMPONI® yourself until you have been shown the right way to give the injections by your doctor or nurse.
- Adults and children 12 years of age and older may self-inject with SIMPONI® prefilled syringe
- Only adults may self-inject with SIMPONI® SmartJect® autoinjector
Not actual size
Once you have been properly trained by your healthcare provider on how to inject your child, you can administer treatment at home using the prefilled syringe.
While dosing may be important, there are other factors to consider. Talk to your child's healthcare provider about treatment options and what might be right for them.
Please refer to the Medication Guide and Instructions for Use, included with your SIMPONI® medication, for more information on injecting with SIMPONI®.
SIMPONI® is intended for use under the guidance and supervision of a physician.
Getting SIMPONI® From a Specialty Pharmacy
Biologic medicines like SIMPONI® require special handling. Specialty pharmacies have experience managing these medicines.
1
Doctor
writes prescription and sends it to a specialty pharmacy
2
Specialty pharmacy
calls you about your insurance coverage and potential out-of-pocket costs
3
Specialty pharmacy
arranges delivery of your medicine
For your convenience, the specialty pharmacy can have your SIMPONI® delivered directly to you. Or, if you prefer, your medicine can be shipped to a treatment center—such as your doctor's office or a hospital—and you can pick it up yourself.
Medicine cost support is available. Learn more.
Biologics are medicines that are genetically engineered from products of living organisms, such as proteins, genes, or antibodies.
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