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How Does SIMPONI® (golimumab) Work

How Does SIMPONI® Work?

Before starting a new medication, it's important to know what it is and how it works. Here's a closer look at SIMPONI®.

SIMPONI® targets and blocks TNF-alpha

SIMPONI® is an anti-TNF biologic medicine. It targets and blocks a protein called TNF-alpha (tumor necrosis factor-alpha).

  • TNF-alpha is made by your immune system
  • People with certain autoimmune diseases have too much TNF-alpha.
    These diseases include:
    — Rheumatoid arthritis
    — Psoriatic arthritis
    — Ankylosing spondylitis
  • Too much TNF-alpha can cause your immune system to attack parts of the body
  • This leads to the familiar symptoms you feel

SIMPONI® targets and binds with extra TNF-alpha. This helps to block an underlying cause of the symptoms. It can bind with 2 forms of TNF-alpha, and it can bind at more than 1 location.

alpha illustrtation

Blocking too much TNF-alpha can make it harder for your body to fight infections. See your doctor regularly. Tell him or her if you have side effects.

SIMPONI® is not for everyone. Only your doctor can decide if SIMPONI® is right for you.