SimponiOne^SM Safe Returns^TM is a unique monthly service offered only to people being treated with SIMPONI^TM. SimponiOne^SM Safe Returns^TM allows you to dispose of your used SmartJect^TM autoinjectors or used prefilled syringes properly, easily, and at no additional cost—right after you use them. No more worrying what to do with them or where they might end up—they’re out of the house and off your mind. Please refer to the Instructions for Use and contact your doctor with remaining questions regarding disposal of used SmartJect^TM autoinjectors or used prefilled syringes.

Once you enroll, you will be sent your first SimponiOne^SM Safe Returns^TM pack. After taking your monthly dose of SIMPONI^TM, follow the instructions to properly pack and mail back your used SmartJect^TM autoinjector or used prefilled syringe for disposal. You’ll receive a new Safe Returns^TM pack regularly every month. Your monthly dose of SIMPONI^TM is provided to you separately by your pharmacist or specialty pharmacy.

SimponiOne^SM Safe Returns^TM is approved only for the disposal of the one used SmartJect^TM autoinjector or one used prefilled syringe that was used to administer SIMPONI^TM.

SimponiOne^SM Safe Returns^TM is offered at no additional cost to people being treated with SIMPONI^TM. Shipping and disposal costs are taken care of by Centocor Ortho Biotech Inc., the manufacturer of SIMPONI^TM.

Used SmartJect^TM autoinjectors and used prefilled syringes are often called "sharps."* Technically, they are classified as Regulated Medical Waste or biohazard waste, and they need to be disposed of according to government guidelines and U.S. postal service regulations for safe handling when returning.

Regulated Medical Waste should only be disposed of in containers specifically designed and approved by the U.S. postal service. These are usually called "sharps containers." Once filled, the sharps container is placed in a plastic bag which is then sealed and placed in a specially designed and labeled postage-paid mail-back box with liner. This mail-back box is sent to what’s called a "permitted medical waste treatment facility," where it is destroyed.

If you are not a SIMPONI^TM patient or enrolled in SimponiOne^SM Safe Returns^TM but you want to find out how to dispose of Regulated Medical Waste, consult your local government guidelines for the best resources in your local area.

*A "sharp" is any object that is contaminated or that may become contaminated through handling or during transportation and is also capable of cutting or penetrating skin or a packing material (eg, a used SmartJect^TM autoinjector or used prefilled syringe fits into this category.)

Open the end of the outer shipping box marked "Open Here." Inside you’ll find the following items:

1. Safe Returns^TM Instruction Guide
2. Postage-paid mail-back box with liner
3. Container tube
4. Plastic bag
5. Shipping documents
6. Medication Guide with Full Prescribing Information

Read and follow the simple instructions in the Safe Returns^TM Instruction Guide.

Remove the container tube from the plastic bag.

Place one used SmartJect^TM autoinjector or one used prefilled syringe, with the injection end facing away from you, in the container tube, and then close the tube by twisting the cap to seal it securely.

Put the closed container tube back into the plastic bag, press the bag shut, and place it in the postage-paid mail-back box.

Seal the mail-back box by exposing the self-adhesive strip on the inside front flap and then press firmly to seal the adhesive. Remove the shipping documents from the plastic pouch on the outside of the mail-back box. Don’t damage the pouch—the completed forms must be reinserted. Confirm the information in Section 1 and make changes if needed. Sign where it says Generator Certificate. Remove the last copy and keep it for your records. (NJ residents keep the first copy only.) Then put the three remaining copies back into the pouch and close it.

Your package can be mailed from a U.S. mailbox, a post office, or anywhere the U.S. postal service arranges pickup. You may also give it to your mail carrier for pickup so it can be delivered to the destruction facility.

Your mail-back box goes to a permitted medical waste treatment facility, which is owned and operated by Stericycle (the leading national medical waste management provider) for destruction.

As outlined in the Safe Returns^TM Instruction Guide included in your Safe Returns^TM pack, DO NOT put anything in the container tube other than one used SmartJect^TM autoinjector or one used prefilled syringe.

Centocor Ortho Biotech Inc., the manufacturer of SIMPONI^TM, does not have access to the final reporting and tracking of disposal and is not liable for anything shipped via Safe Returns^TM, but you can rest assure that SimponiOne^SM Safe Returns^TM disposes of all waste in accordance with all local, state, and federal guidelines and regulations.

Your signature on the shipping documents is a mandatory step in the SimponiOne^SM Safe Returns^TM process, required by U.S. postal service regulations for proper disposal.

Your package can be mailed from a U.S. mailbox, a post office, or anywhere the U.S. postal service arranges pickup. You may also give it to your mail carrier for pickup.

No. Your monthly dose of SIMPONI^TM is provided separately by your pharmacist or specialty pharmacy. If you have any questions, contact your doctor or pharmacist.

Yes. Shipping documents, often called the "manifest," must accompany all shipments of Regulated Medical Waste. For people taking SIMPONI^TM, the shipping documents have been customized and are included in each shipment of the Safe Returns^TM pack.