How to Take SIMPONI®

If your doctor decides to treat you with SIMPONI®, you will need to be trained on the proper way to self-inject SIMPONI® directly under the skin. Then you can inject SIMPONI® in the comfort of your home — just once each month — without having to travel to your doctor’s office for your injection. To learn more, click on a tab below.

Ease-of-Use CommendationSIMPONI® offers two easy-to-use injection options: the SmartJect® autoinjector, designed so you can self-inject without seeing the needle; or the prefilled syringe. Both have been awarded the Ease-of-Use Commendation by the Arthritis Foundation®. You and your doctor can decide which injection device is best for you.

SmartJect® AutoinjectorPrefilled Syringe

SIMPONI® is the first and only self-injectable biologic treatment for adults with moderate to severe rheumatoid arthritis (RA) that requires just one injection each month. SIMPONI® is taken with the medicine methotrexate, as directed.

Once you and your doctor are comfortable with the self-injection process, you will inject SIMPONI® under the skin, just once a month.

Just one injection, once a month

SIMPONI® requires just one injection, once a month. That’s fewer monthly injections than any other anti-TNF biologic medication. While dosing frequency is important, there are other factors to consider. Talk to your doctor about which treatment is right for you.

Recommended dosing for self-injectable anti-TNF biologic medications for moderate to severe RA.

*Indicated trademarks are the registered trademarks of their respective owners.
Dosing schedule presented does not include initial starting doses.

This presentation is not intended to compare the safety, effectiveness, or uses of these treatments. Please refer to each product’s Prescribing Information for recommended dosing and administration. SIMPONI®, as well as ENBREL® and HUMIRA®, are also available in a prefilled syringe.

It’s normal to have concerns about self-injecting.

For most people with moderate to severe RA, active psoriatic arthritis or active ankylosing spondylitis who participated in clinical trials, SIMPONI® injections were pain-free. Less than 1% of people treated with SIMPONI® reported experiencing any injection site pain, and 6% experienced injection site reactions, such as redness, swelling, itching, pain, bruising, or tingling. To learn more about these and other risks, please read the Important Safety Information about SIMPONI® below, and the Medication Guide, and talk with your doctor.

SimponiOne® Support offers a variety of tools and services to help you feel confident when self-injecting with SIMPONI®, including:

  • Nurse Support, online and by phone

    ¿Habla español?
    SimponiOne® offers Spanish-speaking Nurses
    SimponiOne® ofrece enfermeros de habla hispana.

  • SmartJect® autoinjector reusable trainer
  • Injection demonstration videos

For more information on the proper way to inject SIMPONI®, please refer to the Instructions for Use that comes with your SIMPONI® medication.

Selected Important Safety Information

SIMPONI® (golimumab) can lower your ability to fight infections. Serious and sometimes fatal events may occur. There have been reports of serious infections including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that have spread throughout the body. Other possible serious side effects may include lymphoma, skin cancer, a rare and fatal cancer called hepatosplenic T-cell lymphoma, other cancers, hepatitis B, heart failure, nervous system problems, or allergic reactions. To learn more about these and other risks, please read the Important Safety Information, and the
Medication Guide, and talk with your doctor.

Next: Other Important Considerations