Treatments for Ankylosing Spondylitis

While ankylosing spondylitis can’t be cured, there are treatments that can help relieve the pain and stiffness. Some of the typical treatment options your doctor may consider are described below. It’s important to talk to your rheumatologist to determine which treatment is right for you.


Often prescribed by doctors when the symptoms of ankylosing spondylitis first appear, nonsteroidal anti-inflammatory drugs (NSAIDs) help reduce pain and stiffness. Many NSAIDs like ibuprofen (such as Motrin®* and Advil®*) and naproxen (such as Aleve®*) are available at drugstores without a prescription. Others, like indomethacin (Indocin®*), require a prescription. Over time, many people find that NSAIDs may not be enough to provide the symptom relief they require.

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Your doctor may have prescribed a medicine called a DMARD (disease-modifying antirheumatic drug) such as sulfasalazine, to help treat your ankylosing spondylitis if you have pain and stiffness in your hands and feet. While many people are helped by DMARDs, for others, it isn’t enough.


When NSAIDs and DMARDs are not enough, medications known as biologics have been shown to be effective in treating ankylosing spondylitis.

SIMPONI® is the first and only self-injectable biologic treatment for adults with active ankylosing spondylitis that requires just one injection each month.

Once you and your doctor are comfortable with the self-injection process, you will inject SIMPONI® under the skin, just once a month.

Just one injection of SIMPONI® each month relieves the pain and stiffness of active ankylosing spondylitis. Your results may vary.

Selected Important Safety Information

SIMPONI® (golimumab) can lower your ability to fight infections. Serious and sometimes fatal events may occur. There have been reports of serious infections including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that have spread throughout the body. Other possible serious side effects may include lymphoma, skin cancer, a rare and fatal cancer called hepatosplenic T-cell lymphoma, other cancers, hepatitis B, heart failure, nervous system problems, lupus-like syndrome, or allergic reactions. To learn more about these and other risks, please read the Important Safety Information and the Medication Guide, and talk with your doctor.

Next: What is a Biologic?