How SIMPONI® Works
Before starting on a new medication, it's important to know what it is, how it works, and what you can expect from treatment. Here's how SIMPONI® helps relieve both the joint pain and stiffness of active ankylosing spondylitis.
The role of TNF-alpha in Ankylosing Spondylitis.
TNF-alpha (tumor necrosis factor-alpha) is a protein made by your body’s immune system. People with certain autoimmune diseases, such as ankylosing spondylitis, have too much TNF-alpha. This can cause the immune system to attack parts of the body leading to the familiar pain and stiffness that many people with ankylosing spondylitis experience.
SIMPONI® is an anti-TNF biologic medication.
SIMPONI® targets and binds with excess TNF-alpha, helping to block an underlying cause of the symptoms of ankylosing spondylitis. It can bind with two forms of TNF-alpha, and it can bind at more than one location.
It's important to know that blocking too much TNF-alpha can lessen your body's ability to fight infections.
SIMPONI® is the first and only self-injectable biologic treatment for adults with active ankylosing spondylitis that requires just one injection each month.
Once you and your doctor are comfortable with the self-injection process, you will inject SIMPONI® under the skin, just once a month.
SIMPONI® is not for everyone; only your doctor can decide if SIMPONI® is right for you.
What to expect from your treatment with SIMPONI®.
While some people using SIMPONI® may experience symptom relief in just one month, studies show that SIMPONI® can help relieve the pain and stiffness of active ankylosing spondylitis after three months. Your results may vary. Talk with your doctor about your response to SIMPONI®.
Selected Important Safety Information
SIMPONI® (golimumab) can lower your ability to fight infections. Serious and sometimes fatal events may occur. There have been reports of serious infections including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that have spread throughout the body. Other possible serious side effects may include lymphoma, skin cancer, a rare and fatal cancer called hepatosplenic T-cell lymphoma, other cancers, hepatitis B, heart failure, nervous system problems, lupus-like syndrome, or allergic reactions. To learn more about these and other risks, please read the Important Safety Information and the Medication Guide, and talk with your doctor.